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Center for Applied Biotechnology and Molecular Medicine

Publications 2023

* supported by a CABMM Start-up Grant
** performed partly on the CABMM Research Platform

* Mengis T, Herger N, Heggli I, Devan J, Spirig JM, Laux CJ, Brunner F, Farshad M, Distler O, Dudli S
Bone marrow stromal cells in Modic type 1 changes promote neurite outgrowth
Front Cell Dev Biol. 2023 Oct 25;11:1286280
PubMed

Hirch T, Brander N, Schenk F, Pöllmann SJ, Reichenbach J, Schubert R, Modlich U
Expression of a large coding sequence: Gene therapy vectors for Ataxia Telangiectasia
Sci Rep. 2023 Nov 8;13(1):19386
PubMed

** Lu NJ, Hafezi F, Koppen C, Alió Del Barrio JL, Aslanides IM, Awwad ST, Dhubhghaill SN, Pineda R 2nd, Torres-Netto EA, Wang L, Chen SH, Cui LL, Rozema JJ
New keratoconus staging system based OCT
J Cataract Refract Surg. 2023 Nov 1;49(11):1098-1105
PubMed

Porcello A, Hadjab F, Ajouaou M, Philippe V, Martin R, Abdel-Sayed P, Hirt-Burri N, Scaletta C, Raffoul W, Applegate LA, Allémann E, Jordan O, Laurent A
Ex Vivo Functional Benchmarking of Hyaluronan-Based Osteoarthritis Viscosupplement Products: Comprehensive Assessment of Rheological Lubricative, Adhesive, and Stability Attributes
Gels. 2023 Oct 9;9(10):808
PubMed

Maevskaia E, Khera N, Ghayor C, Bhattacharya I, Guerrero J, Nicholls F, Waldvogel C, Bärtschi R, Fritschi L, Salamon D, Özcan M, Malgaroli P, Seiler D, de Wild M, Weber FE
Three-Dimensional Printed Hydroxyapatite Bone Substitutes Designed by a Novel Periodic Minimal Surface Algorithm Are Highly Osteoconductive
3D Print Addit Manuf. 2023 Oct 1;10(5):905-916
PubMed

** Torres-Netto EA, Abdshahzadeh H, Lu NJ, Kling S, Abrishamchi R, Hillen M, Hafezi N, Koppen C, Hafezi F
Corneal Cross-Linking With Riboflavin Using Sunlight
J Cataract Refract Surg. 2023 Oct 1;49(10):1049-1055
PubMed

Maevskaia E, Guerrero J, Ghayor C, Bhattacharya I, Weber FE
Triply Periodic Minimal Surface-Based Scaffolds for Bone Tissue Engineering: A Mechanical, In Vitro and In Vivo Study
Tissue Eng Part A. 2023 Oct;29(19-20):507-517
PubMed

Meyer DC, Bachmann E, Darwiche S, Moehl A, von Rechenberg B, Gerber C, Snedeker JG
Rotator Cuff Repair and Overlay Augmentation by Direct Interlocking of a Nonwoven Polyethylene Terephthalate Patch Into the Tendon: Evaluation in an Ovine Model
Am J Sports Med. 2023 Oct;51(12):3235-3242
PubMed

de Wild M, Zimmermann S, Klein K, Steffen T, Schlottig F, Hasler C, von Rechenberg B
Immediate stabilization of pedicle screws
Curr Dir Biomed Eng. 2023 Sep 20;9(1):13-16
De Gruyter

Chen X, Laurent A, Liao Z, Jaccoud S, Abdel-Sayed P, Flahaut M, Scaletta C, Raffoul W, Applegate LA, Hirt-Burri N
Cutaneous Cell Therapy Manufacturing Timeframe Rationalization: Allogeneic Off-the-Freezer Fibroblasts for Dermo-Epidermal Combined Preparations (DE-FE002-SK2) in Burn Care
Pharmaceutics. 2023 Sep 16;15(9):2334
PubMed

Philippe V, Jeannerat A, Peneveyre C, Jaccoud S, Scaletta C, Hirt-Burri N, Abdel-Sayed P, Raffoul W, Darwiche S, Applegate LA, Martin R, Laurent A
Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benckmarking and Parallel Functional Qualification
Pharmaceutics. 2023 Sep 16;15(9):2333
PubMed

** Olshaker H, Achiron A, Chorny A, Hafezi F, Yahalomi T, Kratz A, Tsumi E, Lu NJ, Knyazer B
Accelerated high fluence photoactivated chromophore for infectious keratitis-corneal cross-linking (PACK-CXL) at the slit lamp: a pilot study
Front Pharmacol. 2023 Sep 7;14:1229095
PubMed

** Hafezi F, de Almeida Torres-Netto E, Kollros L, Lu NJ, Hafezi N, Mazzotta C, Aydemir ME, Hillen M
Rates of infectious keratitis and other ocular surface adverse events in corneal cross-linking for keratoconus and corneal ectasias performed in an office-based setting: a retrospective cohort study
Eye Vis (Lond). 2023 Sep 1;10(1):36
PubMed

** Lu NJ, Koliwer-Brandl H, Hillen M, Egli A, Hafezi F
High-Fluence Accelerated PACK-CXL for Bacterial Keratitis Using Riboflavin/UV-A or Rose Bengal/Green in the Ex Vivo Porcine Cornea
Transl Vis Sci Technol. 2023 Sep 1;12(9):14
PubMed

Jeannerat A, Meuli J, Peneveyre C, Jaccoud S, Chemali M, Thomas A, Liao Z, Abdel-Sayed P, Scaletta C, Hirt-Burri N, Applegate LA, Raffoul W, Laurent A
Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine
Pharmaceutics. 2023 Jul 3;15(7):1873
PubMed

** Hafezi F, Torres-Netto EA, Hillen M
Expanding indications for corneal cross-linking
Curr Opin Ophthalmol. 2023 Jul 1;34(4):339-347
PubMed

** Gomes JAP, Azar DT, Baudouin C, Bitton E, Chen W, Hafezi F, Hamrah P, Hogg RE, Horwath-Winter J, Kontadakis GA, Mehta JS, Messmer EM, Perez VL, Zadok D, Willcox MDP
TFOS Lifestyle: Impact of elective medications and procedures on the ocular surface
Ocul Surf. 2023 Jul;29:331-385
PubMed

** Ambrósio R Jr, Machado AP, Leão E, Lyra JMG, Salomão MQ, Esporcatte LGP, Filho JBRDF, Ferreira-Meneses E, Sena NB Jr, Haddad JS, Neto AC, Castelo de Almeida G Jr, Roberts CJ, Elsheikh A, Vinciguerra R, Vinciguerra P, Bühren J, Kohnen T, Kezirian GM, Hafezi F, Hafezi NL, Torres-Netto EA, Lu N, Kang DSY, Kermani O, Koh S, Padmanabhan P, Taneri S, Trattler W, Gualdi L, Salgado-Borges J, Faria-Correia F, Flockerzi E, Seitz B, Jhanji V, Chan TCY, Baptista PM, Reinstein DZ, Archer TJ, Rocha KM, Waring GO 4th, Krueger RR, Dupps WJ, Khoramnia R, Hashemi H, Asgari S, Momeni-Moghaddam H, Zarei-Ghanavati S, Shetty R, Khamar P, Belin MW, Lopes B; International Corneal and Ocular and Biomechanics Study Group.
Optimized artificial intelligence for enhanced ectasia detection using Scheimpflug-based corneal tomography and biomechanical data
Am J Ophthalmol. 2023 Jul;251:126-142
PubMed

Plath AMS, Huber S, Alfarano SR, Abbott DF, Hu M, Mougel V, Isa L, Ferguson SJ
Co-Electrospun Poly(ε-Caprolactone)/Zein Articular Cartilage Scaffolds
Bioengineering (Basel). 2023 Jun 27;10(7):771
PubMed

Darwiche SE, Kaczmarek A, Schwarzenberg P, Inglis BJ, Lechmann B, Kronen P, Ferguson SJ, Dailey H, von Rechenberg B, Klein K
Combined electric and magnetic field therapy for bone repair and regeneration: an investigation in a 3-mm and an augmented 17-mm tibia osteotomy model in sheep
J Orthop Surg Res. 2023 Jun 24;18(1):454
PubMed

Traber J, Wild T, Marotz J, Berli MC, Franco-Obregon A
Concurrent Optical- and Magnetic-Stimulation-Induced Changes on Wound Healing Parameters, Analyzed by Hyperspectral Imaging: An Exploratory Case Series
Bioengineering (Basel). 2023 Jun 23;10(7):750
PubMed

Reiländer S, Schmehl W, Popp K, Nuss K, Kronen P, Verdino D, Wiezorek C, Gutmann M, Hahn L, Däubler C, Meining A, Raschig M, Kaiser F, von Rechenberg B, Scherf-Clavel O, Meinel L
Oral Use of Therapeutic Carbon Monoxide for Anyone, Anywhere, and Anytime
ACS Biomater Sci Eng. 2023 Jun 12;9(6):2937-2948
PubMed

** Lu NJ, Koppen C, Hafezi F, Ní Dhubhghaill S, Aslanides IM, Wang QM, Cui LL, Rozema JJ
Combinations of Scheimpflug tomography, ocular coherence tomography and air-puff tonometry improve the detection of keratoconus
Cont Lens Anterior Eye. 2023 Jun;46(3):101840
PubMed

Porcello A, Gonzalez-Fernandez P, Jeannerat A, Peneveyre C, Abdel-Sayed P, Scaletta C, Raffoul W, Hirt-Burri N, Applegate LA, Allémann E, Laurent A, Jordan O
Thermo-Responsive Hyaluronan-Based Hydrogels Combined with Allogeneic Cytotherapeutics for the Treatment of Osteoarthritis
Pharmaceutics. 2023 May 18;15(5):1528
PubMed

* Dudli S, Heggli I, Laux CJ, Spirig JM, Wanivenhaus F, Betz M, Germann C, Farshad-Amacker N, Herger N, Mengis T, Brunner F, Farshad M, Distler O
Role of C-reactive protein in the bone marrow of Modic type 1 changes
J Orthop Res. 2023 May;41(5):1115-1122
PubMed

** Kollros L, Torres-Netto EA, Rodriguez-Villalobos C, Hafezi NL, Hillen M, Lu NJ, Hafezi F
Progressive keratoconus in patients older than 48 years
Cont Lens Anterior Eye. 2023 Apr;46(2):101792
PubMed

Sebbagh P, Hirt-Burri N, Scaletta C, Abdel-Sayed P, Raffoul W, Gremeaux V, Laurent A, Applegate LA, Gremion G
Process Optimization and Efficacy Assessment of Standardized PRP for Tendinopathies in Sports Medicine: Retrospective Study of Clinical Files and GMP Manufacturing Records in a Swiss University Hospital
Bioengineering (Basel). 2023 Mar 25;10(4):409
PubMed

Guerrero J, Maevskaia E, Ghayor C, Bhattacharya I, Weber FE
Influence of Scaffold Microarchitecture on Angiogenesis and Regulation of Cell Differentiation during the Early Phase of Bone Healing: A Transcriptomics and Histological Analysis
Int J Mol Sci. 2023 Mar 22;24(6):6000
PubMed

Casanova EA, Rodriguez-Palomo A, Stähli L, Arnke K, Gröninger O, Generali M, Neldner Y, Tiziani S, Dominguez AP, Guizar-Sicairos M, Gao Z, Appel C, Nielsen LC, Georgiadis M, Weber FE, Stark W, Pape HC, Cinelli P, Liebi M
SAXS imaging reveals optimized osseointegration properties of bioengineered 3D-PLGA/aCaP scaffolds in a critical size bone defect model
Biomaterials. 2023 Mar;294:121989
PubMed

** Lu NJ, Hafezi F, Torres-Netto EA, Assaf JF, Aslanides IM, Awwad ST, Chen S, Cui LL, Koppen C
Effect of fluence levels on prophylactic corneal cross-linking for laser in situ keratomileusis and transepithelial photorefractive keratectomy
Acta Ophthalmol. 2023 Mar;101(2):e185-e196
PubMed

Thomson BR, Richter H, Akeret K, Buzzi RM, Anagnostakou V, van Niftrik CHB, Schwendinger N, Kulcsar Z, Kronen PW, Regli L, Fierstra J, Schaer DJ, Hugelshofer M
Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity
J Stroke Cerebrovasc Dis. 2023 Mar;32(3):106985
PubMed

Wang S, Lädermann A, Chiu J, Nabergoj M, Ho SWL, Brigitte VR, Bothorel H, Lädermann L, Kolo F
Muscle Edema of Retraction and Pseuso-Fatty Infaltration After Traumatic Rotator Cuff Tears: An Experimental Model in Sheep
Orthop J Sports Med. 2023 Feb 28;11(2):23259671231154275
PubMed

Wang S, Lädermann A, Chiu J, Nabergoj M, Ho SWL, Brigitte VR, Bothorel H, Lädermann L, Kolo F
Muscle Edema of Retraction and Pseuso-Fatty Infaltration After Traumatic Rotator Cuff Tears: An Experimental Model in Sheep
Orthop J Sports Med. 2023 Feb 28;11(2):23259671231154275
PubMed

Sebbagh P, Cannone A, Gremion G, Gremeaux V, Raffoul W, Hirt-Burri N, Michetti M, Abdel-Sayed P, Laurent A, Wardé N, Applegate LA
Current Status of PRP Manufacturing Requirements & Regulatory Frameworks: Practical Tools for the Appropriate Implementation of PRP Therapies in Musculoskeletal Regenerative Medicine
Bioengineering (Basel). 2023 Feb 24;10(3):292
PubMed

** Lu NJ, Koliwer-Brandl H, Gilardoni F, Hafezi N, Knyazer B, Achiron A, Zbinden R, Egli A, Hafezi F
The Antibacterial Efficacy of High-Fluence PACK Cross-Linking Can Be Accelerated
Transl Vis Sci Technol. 2023 Feb 1;12(2):12
PubMed

** Kollros L, Lu N, Hillen M, Torres-Netto EA, Hafezi F
Scleral contact lenses fitted to extremely steep corneas
J Fr Ophthalmol. 2023 Feb;46(2):e70-e74
PubMed

Jenner F, Wagner A, Gerner I, Ludewig E, Trujanovic R, Rohde E, von Rechenberg B, Gimona M, Traweger A
Evaluation of the Potential of Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles to Improve Rotator Cuff Healing: A Pilot Ovine Study
Am J Sports Med. 2023 Feb;51(2):331-342
PubMed

Laurent A, Scaletta C, Abdel-Sayed P, Raffoul W, Hirt-Burri N, Applegate LA
Industrial Biotechnology Conservation Processes: Similarities with Natural Long-Term Preservation of Biological Organisms
BioTech. 2023 Jan 31;12(1):15
PubMed

Laurent A, Porcello A, Jeannerat A, Peneveyre C, Coeur A, Abdel-Sayed P, Scaletta C, Michetti M, de Buys Roessingh A, Jordan O, Allémann E, Raffoul W, Hirt-Burri N, Applegate LA
Lyophilized Progenitor Tenocyte Extracts: Sterilizable Cytotherapeutic Derivatives with Antioxidant Properties and Hyaluronan Hydrogel Functionalization Effects
Antioxidants (Basel). 2023 Jan 10;12(1):163
PubMed

Laurent A, Rey M, Scaletta C, Abdel-Sayed P, Michetti M, Flahaut M, Raffoul W, de Buys Roessingh A, Hirt-Burri N, Applegate LA
Retrospectives on Three Decades of Safe Clinical Experience with Allogeneic Dermal Progenitor Fibroblasts: High Versatility in Topical Cytotherapeutic Care
Pharmaceutics. 2023 Jan 4;15(1):184
PubMed

** Torres-Netto EA, Hafezi F, Kling S
Reply: Mechanisms of Corneal Strengthening by Ring Implants
J Refract Surg. 2023 Jan;39(1):66-67
PubMed

Rüger M, Seitz AM, Nuss K, von Rechenberg B, Seitz D, Kostmann C, Quadbeck P, Andersen O, Collins C
A Bioinspired Orthopedic Biomaterial with Tunable Mechanical Properties Based on Sintered Titanium Fibers
Adv Healthc Mater. 2023 Jan;12(2):e2202106
PubMed

Darwiche SE, Tegelkamp M, Nuss K, von Rechenberg B
Histological Preparation and Evaluation of Cartilage Specimens
Methods Mol Biol. 2023;2598:227-263
PubMed