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Center for Applied Biotechnology and Molecular Medicine

Associated publications

Mengis T, Herger N, Heggli I, Devan J, Spirig JM, Laux CJ, Brunner F, Farshad M, Distler O, Dudli S
Bone marrow stromal cells in Modic type 1 changes promote neurite outgrowth.
Front Cell Dev Biol. 2023 Oct 25;11:1286280
PubMed

Dudli S, Heggli I, Laux CJ, Spirig JM, Wanivenhaus F, Betz M, Germann C, Farshad-Amacker NA, Herger N, Mengis T, Brunner F, Farshad M, Distler O
Role of C-reactive protein in the bone marrow of Modic type 1 changes.
J Orthop Res. 2023 May;41(5):1115-1122
PubMed

Bakirci E, Guenat OT, Ahmad SS, Gantenbein B
Tissue engineering approaches for the repair and regeneration of the anterior cruciate ligament: towards 3D bioprinted ACL-on-chip.
Eur Cell Mater. 2022 Aug 8;44:21-42
PubMed

Rodríguez JMM, Fonfara S, Hetzel U, Kipar A
Feline hypertrophic cardiomyopathy: reduced microvascular density and involvement of CD34+ interstitial cells.
Vet Pathol. 2022 Mar;59(2):269-283
PubMed

Herger N, Bermudez-Lekerika P, Farshad M, Albers CE, Distler O, Gantenbein B, Dudli S
Should Degenerated Intervertebral Discs of Patients with Modic Type 1 Changes Be Treated with Mesenchymal Stem Cells?
Int J Mol Sci. 2022 Feb 28;23(5):2721
PubMed

Mainardi A, Cambria E, Occhetta P, Martin I, Barbero A, Schären S, Mehrkens A, Krupkova O
Intervertebral Disc-on-a-Chip as Advanced In Vitro Model for Mechanobiology Research and Drug Testing: A Review and Perspective.
Front Bioeng Biotechnol. 2022 Jan 28;9:826867
PubMed

Generali M, Kehl D, Wanner D, Okoniewski MJ, Hoerstrup SP, Cinelli P
Heterogeneous expression of ACE2 and TMPRRS2 in mesenchymal stromal cells.
J Cell Mol Med. 2022 Jan;26(1):228-234
PubMed

Gantenbein B, May RD, Bermudez-Lekerika P, Oswald KAC, Benneker LM, Albers CE
EGR2, IGF1 and IL6 Expression Are Elevated in the Intervertebral Disc of Patients Suffering from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Compared to Degenerative or Trauma Discs.
Appl Sci. 2021;11(9):4072
MDPI

Mallone A, Gericke C, Hosseini V, Vogel V, Chahbi K, Walther JH, Haenseler W, von Eckardstein A, Emmert MY, Weber B, Hoerstrup SP
Human induced pluripotent stem cell-derived arteries as personalized models of atherosclerosis on-a-chip.
bioRxiv. 2020 Nov 27 [preprint]
bioRxiv

Schmidli MR, Sadowska A, Cvitas I, Gantenbein B, Lischer HEL, Forterre S, Hitzl W, Forterre F, Wuertz-Kozak K
Fibronectin Fragments and Inflammation During Canine Intervertebral Disc Disease.
Front Vet Sci. 2020 Nov 16;7:547644
PubMed

Capossela S, Mathew V, Boos M, Bertolo A, Krupkova O, Stoyanov JV
Novel Fast and Reliable Method for Nano-Erythrosome Production Using Shear Force.
Drug Des Devel Ther. 2020 Oct 28;14:4547-4560
PubMed

Gantenbein B, Croft AS, Larraillet M
Mammalian Cell Viability Methods in 3D Scaffolds for Tissue Engineering.
Fluorescence Methods for Investigation of Living Cells and Microorganisms, Natalia Grigoryeva, IntechOpen.
2020 Sep 30

IntechOpen

Bakirci E, Tschan K, May RD, Ahmad SS, Kleer B, Gantenbein B
The importance of plasmin for the healing of the anterior cruciate ligament.
Bone Joint Res. 2020 Sep 3;9(9):543-553
PubMed

Cornaz F, Valet S, Meyer DC
Spectroscopic characterization of tissue and liquids during arthroscopic radio-frequency ablation.
Med Phys, 2020 Aug;47(8):3703-3709

PubMed

Nytko KJ, Thumser-Henner P, Russo G, Weyland MS, Rohrer Bley C
Role of HSP70 in response to (thermo)radiotherapy: analysis of gene expression in canine osteosarcoma cells by RNA-seq.
Sci Rep. 2020 Jul 29;10(1):12779
PubMed

Filippo Buono M, von Boehmer L, Strang J, Hoerstrup SP, Emmert MY, Nugraha B
Human Cardiac Organoids for Modeling Genetic Cardiomyopathy.
Cells. 2020 Jul 20;9(7):1733
PubMed

Schmid B, Hausmann O, Hitzl W, Achermann Y, Wuertz-Kozak K
The Role of Cutibacterium acnes in Intervertebral Disc Inflammation.
Biomedicines, 2020 Jun 30;8(7):186

PubMed

May RD, Frauchiger DA, Albers CE, Hofstetter W, Gantenbein B
Exogenous Stimulation of Human Intervertebral Disc Cells in 3-Dimensional Alginate Bead Culture With BMP2 and L51P: Cytocompatibility and Effects on Cell Phenotype.
Neurospine, 2020 Mar;17(1):77-87

PubMed

Krupkova O, Greutert H, Boos N, Lemcke J, Liebscher T, Wuertz-Kozak K
Expression and activity of hyluronidases HYAL-1, HYAL-2 and HYAL-3 in the human intervertebral disc.
Eur Spine J, 2020 Mar;29(3):605-615

PubMed

Barreto G, Senturk B, Colombo L, Brück O, Neidenbach P, Salzmann G, Zenobi-Wong M, Rottmar M
Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization.
Osteoarthritis Cartilage, 2020 Jan;28(1):92-101

PubMed

Loepfe M, Duss A, Zafeiropoulou KA, Björgvinsdóttir O, D`Este M, Eglin D, Fortunato G, Klasen J, Ferguson SJ, Wuertz-Kozak K, Krupkova O
Electrospray-Based Microencapsulation of Epigallocatechin 3-Gallate for Local Delivery into the Intervertebral Disc.
Pharmaceutics, 2019 Sep 1;11(9):435

PubMed

Kehl D, Generali M, Mallone A, Heller M, Uldry AC, Cheng P, Gantenbein B, Hoerstrup SP, Weber B
Proteomic analysis of human mesenchymal stromal cell secretome: a systemic comparison of the angiogenic potential.
NPJ Regen Med, 2019 Apr 16;4:8

PubMed

Cavalli E, Levinson C, Hertl M, Broguiere N, Brück O, Mustjoki S, Gerstenberg A, Weber D, Salzmann G, Steinwachs M, Barreto G, Zenobi-Wong M
Characterization of polydactyly chondrocytes and their use in cartilage engineering.
Sci Rep, 2019 Mar 12;9(1):4275

PubMed

Lee M, Bae K, Guillon P, Chang J, Arlov O, Zenobi-Wong M
Exploitation of Cationic Silica Nanoparticles for Bioprinting of Large-Scale Constructs with High Printing Fidelity.
ACS Appl Mater Interfaces, 2018 Nov 7;10(44):37820-37828

PubMed

Cavalli E, Fisch P, Formica FA, Gareus R, Linder T, Applegate LA, Zenobi-Wong M
A comparative study of cartilage engineered constructs in immunocompromised, humanized and immunocompetent mice.
J Immunol Regen Med, 2018 Sep;2:36-46

ScienceDirect

Schmidli MR, Fuhrer B, Kurt N, Senn D, Drögemüller M, Rytz U, Spreng DE, Forterre S
Inflammatory pattern of the infrapatellar fat pad in dogs with canine cruciate ligament disease.
BMC Vet Res, 2018 May 16;14(1):161

PubMed

Krupkova O, Smolders L, Wuertz-Kozak K, Cook J, Pozzi A
The Pathobiology of the Meniscus: A Comparison Between the Human and Dog.
Front Vet Sci, 2018 Apr 6;5:73

PubMed

Bertolo A, Pavlicek D, Gemperli A, Baur M, Pötzel T, Stoyanov J
Increased motility of mesenchymal stem cells is correlated with inhibition of stimulated peripheral blood mononuclear cells in vitro.
J Stem Cells Regen Med, 2017 Dec 18;13(2):62-74

PubMed

Monchaux M, Forterre S, Spreng D, Karol A, Forterre F, Wuertz-Kozk K
Inflammatory Processes Associated with Canine Intervertebral Disc Herniation.
Front Immunol, 2017 Dec 4;8:1681

PubMed

Krismer AM, Cabra RS, May RD, Frauchiger DA, Kohl S, Ahmad SS, Gantenbein B
Biologic response of human anterior cruciate ligamentocytes on collagen-patches to platelet-rich plasma formulations with and without leucocytes.
J Orthop Res, 2017 Dec;35(12):2733-2739

PubMed

Öztürk E, Despot-Slade E, Pichler M, Zenobi-Wong M
RhoA activation and nuclearization marks loss of chondrocyte phenotype in crosstalk with Wnt pathway.
Exp Cell Res, 2017 Nov 15;360(2):113-124

PubMed

Studer D, Cavalli E, Formica FA, Kuhn GA, Salzmann G, Mumme M, Steinwachs MR, Laurent-Applegate, Maniura-Weber K, Zenobi-Wong M
Human chondroprogenitors in alginate-collagen hybrid scaffolds produce stable cartilage in vivo.
J Tissue Eng Regen Med, 2017 Nov;11(11):3014-3016

PubMed

Öztürk E, Hobiger S, Despot-Slade E, Pichler M, Zenobi-Wong M
Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes.
Sci Rep, 2017 Aug 22;7(1):9032

PubMed

Mirsaidi A, Tiaden AN, Richards PJ
Prostaglandine E2 inhibits matrix mineralization by human bone marrow stromal cell-derived osteoblasts via Epac-dependent cAMP signaling.
Sci Rep, 2017 May 22;7(1):2243

PubMed

Frank-Bertoncelj M, Trenkmann M, Klein K, Karouzakis E, Rehrauer H, Bratus A, Kolling C, Armaka M, Filer A, Michel BA, Gay RE, Buckley CD, Kollias G, Gay S, Ospelt C
Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions.
Nat Commun, 2017 Mar 23;8:14852

PubMed

Ghayor C, Gjoksi B, Dong J, Siegenthaler B, Calfisch A, Weber FE
N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.
Sci Rep, 2017 Feb 8;7:42108

PubMed

Krupkova O, Handa J, Hlavna M, Klasen J, Ospelt C, Ferguson SJ, Wuertz-Kozak K
The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress.
Oxid Med Cell Longev, 2016;2016:7031397

PubMed

Robaszkiewicz A, Qu C, Wisnik E, Ploszaj T, Mirsaidi A, Kunze FA, Richards PJ, Cinelli P, Mbalaviele G, Hottiger MO
ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β.
Sci Rep, 2016 Feb 17;6:21131

PubMed

Krupkova O, Hlavna M, Amir Tahmasseb J, Zvick J, Kunz D, Ito K, Ferguson SJ, Wuertz-Kozak K
An Inflammatory Nucleus Pulposus Tissue Culture Model to Test Molecular Regenerative Therapies: Validation with Epigallocatechin 3-Gallate.
Int J Mol Sci, 2016 Sep 27;17(10)

PubMed

Kuemmerle JM, Theiss F, Okoniewski MJ, Weber FA, Hemmi S, Mirsaidi A, Richards PJ, Cinelli P
Identification of Novel Equine (Equus caballus) Tendon Markers Using RNA Sequencing.
Genes (Basel), 2016 Nov 10;7(11)

PubMed

Broguiere N, Cavalli E, Salzmann GM, Applegate LA, Zenobi-Wong, M
Factor XIII Cross-Linked Hyaluronan Hydrogels for Cartilage Tissue Engineering.
ACS Biomater Sci Eng, 2016;2(12),pp 2176–2184

Webpage

Gantenbein B, Calandriello E, Wuertz-Kozak K, Benneker LM, Keel MJ, Chan SC
Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia.
BMC Musculoskelet Disord, 2014 Dec 11;15:422

PubMed

Klawitter M, Hakozaki M, Kobayashi H, Krupkova O, Quero L, Ospelt C, Gay S, Hausmann O, Liebscher T, Meier U, Sekiguchi M, Konno SI, Boos N, Ferguson SJ, Wuertz K
Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells.
Eur Spine J, 2014 Sep;23(9):1878-91

PubMed

Lindtner RA, Tiaden AN, Genelin K, Ebner HL, Manzl C, Klawitter M, Sitte I, Rechenberg BV, Blauth M, Richards PJ
Osteoanabolic effect of alendronate and zoledronate on bone marrow stromal cells (BMSCs) isolated from aged female osteoporotic patients and its implications for their mode of action in the treatment of age-related bone loss.
Osteoporos Int, 2014 Mar;25(3):1151-61

PubMed

Guetg C, Scheifele F, Rosenthal F, Hottiger MO, Santoro R
Inheritance of Silent rDNA Chromatin Is Mediated by PARP1 via Noncoding RNA.
Mol Cell, 2012 Mar 30;45(6):790-800

PubMed

Tiaden AN, Breiden M, Mirsaidi A, Weber FA, Bahrenberg G, Glanz S, Cinelli P, Ehrmann M, Richards PJ
Human Serine Protease HTRA1 Positively Regulates Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells and Mineralization of Differentiating Bone- Forming Cells through the Modulation of Extracellular Matrix Protein.
Stem Cells, 2012;30:2271-2282

PubMed

Tiaden AN, Klawitter M, Lux V, Mirsaidi A, Bahrenberg G, Glanz S, Quero L, Liebscher T, Wuertz K, Ehrmann M, Richards PJ
Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration.
J Biol Chem, 2012;287(25):21335-45

PubMed